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Evidence is increasing that all addiction without exception is related to difficulty with the brain's reward center, especially the mesolimbic system. This section of the problem regulates reward responses in getting food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both whenever they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in in response to a stimulus"(Bostwick & Bucci, 2008).
Using two separate drugs to shed pounds can be very effective you will find combinations in front of the FDA now awaiting approval. When dealing with weight loss and the individuals who go through it you should err on the side of caution and permit the FDA do its job and demand some study be done in order that the public is aware of the side effects and perils associated with the medications before we drive them. Keep in mind that drug companies are in business to generate income and that they would say almost anything to keep people on their own medications.
Researchers found that participants using this drug for any year, lost weight within four weeks and have kept the weight off throughout the 56 weeks of the study. Contrave is a combination of the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs which might be made up of many active ingredient, that might make them more potent and safer.
Combo-pilling is the newest fad or even better the newest in the future under scrutiny and for that reason it is just more publicly known lately, comb-pilling for losing weight has been around since the eighties. The biggest reason that utilizing a combination of pills is now popular may be the fact that as of right now there are not any long term prescription diet pills that have been authorized by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations are already rejected or have yet to be licensed by the FDA.
Seizures certainly are a side effect with Contrave and really should not be taken in people with seizure disorders. The drug could also raise blood pressure levels and heartbeat, and mustn't be used in those with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with all the drug.
The FDA also warned that Contrave can raise blood pressure levels and pulse rate and must 't be used in patients with uncontrolled high hypertension, in addition to by you are not heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients which has a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes having a boxed warning to alert health care professionals and patients for the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stop smoking.
New UCLA study on smokers with mental, drug, and alcohol problems